Bale gave Tottenham the lead after just 68 seconds, knocking in a cross from Son Heung-min after defender James Tarkowski missed a chance to intercept.
Jesse Lingard scored what proved to be the winning goal in the 47th minute after running onto a pass from Pablo Fornals and burying an angled shot with his left foot.
Bale missed the FA Cup game on Wednesday against Everton after reporting an unspecified injury.
Villa requested for its game against Tottenham to be rescheduled, the league said Monday, after a coronavirus outbreak at its training ground last week that led to 14 positive cases — 10 among players.
Jose Mourinho reached his first final as Tottenham manager after Son Heung-min and Moussa Sissoko clinched a 2-0 victory over Brentford in the League Cup on Tuesday.
South Korea forward has reached a century of goals in his sixth season at Tottenham, which won its first league game in a month.
Tottenham's once-blossoming title challenge has faltered over the last eight days, with only one point collected by Jose Mourinho's side from three games.
Kane collected a short pass from Son and sent in a speculative, swerving shot from about 30 meters (yards) that befuddled Palace goalkeeper Vicente Guaita and flew into the middle of the goal in the 23rd minute.
It was a wonder goal from Son that put Spurs in front in the 13th minute. Freed down the left by Kane, the South Korean cut inside and curled a brilliant 25-yard (meter) strike into the top corner.
In 2018-19, Tottenham made a profit of 68.6 million pounds ($91.7 million) during its first partial season in its new 1.2 billion-pound ($1.6 billion) stadium.
Ten-man Benfica came from two goals down to draw 3-3 with Rangers after an equalizer in injury time, and Arsenal had to come from one goal down to beat Norwegian club Molden 4-1 at home for its third straight win.
A lead protected this time, Jose Mourinho’s side climbed to second in the Premier League on the day his former club Manchester United lost 1-0 at home to Arsenal.
Son headed in from Kane's flick-on to secure a 1-0 win at Burnley on Monday, making it the 29th time they have combined for a goal. It was the ninth time in six league matches this season alone.
North London rival Arsenal opened its fourth straight Europa League campaign with a 2-1 come-from-behind win at Rapid Vienna in an opening round of games affected by the coronavirus pandemic.
Cruising 3-0 when Bale came off in the bench in the 72nd minute against West Ham, Tottenham incredibly collapsed in a game it had been in control of to draw 3-3 in the Premier League on Sunday.
A header by Newcastle substitute Andy Carroll struck the outstretched arm of Eric Dier — who was looking the other way — inside the area and the referee awarded a penalty after viewing the incident on the pitchside monitor.
There were no major upsets as Tottenham, Celtic, Wolfsburg, PSV Eindhoven and Sporting Lisbon all advanced to the playoff round.
After opening the league season with a loss to Everton, Tottenham registered its first win a day after Gareth Bale returned to the London club.
Milan visited Ireland 45 years ago to draw 0-0 with Athlone Town in a UEFA Cup second round, first-leg game. Milan won the return game 3-0.
Kane posted a heartfelt message for the duo on social media, seemingly to say goodbye.
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