Awaran district where the quake was centered has been a stronghold of the separatists. Even among Baluchistan residents who aren't part of the armed conflict, there is strong resentment against the central government, which many residents contend exploits the southwestern province's oil, natural gas and mineral deposits.
On Saturday, gunmen killed four Pakistani troops carrying rations for earthquake victims.
Last week, militants fired on two helicopters, including one carrying top government officials surveying the damage. No one was wounded in the incidents.
Wednesday's bombing at the Pakistan-Afghan border took place at a land crossing located in the Pakistani town of Chaman, some 480 kilometers south of the earthquake zone, said security officials.
The six people who were killed were civilians. The wounded included six Pakistani border guards and five civilians, said the officials, also speaking on condition of anonymity because they were not authorized to talk to the media.
No one has claimed responsibility for the attack. In addition to separatists, Baluchistan is also home to Islamic militants who periodically carry out attacks against both civilians and Pakistani security forces.
