Inter Milan progressed into the Champions League quarterfinals after the Italian club won 1-0 at Chelsea.
Samuel Eto'o scored with 12 minutes left to end Chelsea's 21-match unbeaten streak at home in the Champions League.
Inter Milan clinched a 3-1 aggregate win and walked into the last eight for the first time in four years.
Eto'o was the hero of the match when he beat offside to finish Wesley Sneijder's floated free kick with a low shot past goalkeeper Ross Turnbull.
With Chelsea pressing for an equalizer, Eto'o almost scored a second in injury time but Turnbull saved with his feet.
Eto'o had Inter's best chance in the first half when Chelsea captain John Terry misjudged a cross from Maicon, but Eto'o failed to connect properly.
Shortly before the break Chelsea again came close, but Walter Samuel managed to block Malouda's shot.
Inter broke the deadlock in the 78th minute when an accurate pass from Wesley Sneijder sent Eto'o through and the Cameroon striker slot past Chelsea's third choice goalkeeper Ross Turnbull.
Any hope Chelsea had of coming back into the game were killed off five minutes from the end when Drogba was shown a straight red card for stomping on Thiago Motta.
Eto'o came close to making it two for his side when he was again sent through in injury time, but Turnbull managed to pull off a good save to deny the striker.
Mourinho will be without defenders Motta and Lucio for their first leg quarterfinals after both of them received their second booking in the tournament.
For Chelsea it is only the second time in seven seasons that they have failed to advance at least to the semifinals of the Champions League.
