The fourth seed, who is on a winning streak since the start of the Tokyo Olympics in July, raced past Harris, 7-6(6), 6-3, 6-4 at the Flushing Meadows.
The Russian, who captured his 200th career win in the first-round victory against Richard Gasquet of France, defeated qualifier Botic van de Zandschulp in four sets.
Canadian Felix Auger-Aliassime made his first major semifinal at the US Open after Spanish giant-killer Carlos Alcaraz retired due to an undisclosed injury 6-3, 3-1.
The 19-year-old Canadian tennis sensation defeated Elina Svitolina over three sets 6-3, 3-6, 7-6 (5) to reach her maiden Grand Slam semi-finals.
Bopanna and Dodig, seeded 13th, lost 7-6(4) 4-6 6-7(3) to fourth seeds Rajeev Ram and Joe Salisbury in the third round.
This was Andreescu’s first loss in the main draw at Flushing Meadows. She beat Serena Williams in the final to win the title in her debut two years ago and missed the hard-court Grand Slam tournament in 2020
Harris will face fourth seed Alexander Zverev in the last eight after the German moved past Italian Jannik Sinner 6-4, 6-4, 7-6(7).
Fernandez will be up against No. 5 seed Elina Svitolina while Alcaraz plays the final match of the day on Ashe against No. 12 seed Felix Auger-Aliassime
No. 1 Djokovic improved to 25-0 in majors this year by winning 1-6, 6-3, 6-2, 6-2 against 20-year-old Jenson Brooksby.
Following a tame defeat to Raducanu, Rogers said she kind of wished social media didn't exist, because hers was going to be filled with negativity.
The Olympic gold medalist from Switzerland beat Iga Swiatek 7-6 (12), 6-3 to make the last eight in Flushing Meadows for the third time.
Brooksby is a wild-card entry who began this season ranked outside the top 300 and is now a career-best 99th.
Muguruza reportedly told the reigning French Open champion that her behaviour was 'so unprofessional' after the match ended after 1 AM following Krejcikova's medical break.
A day before her 19th birthday, the unseeded left-hander from Canada grabbed the last five games to eliminate 2016 title winner Angelique Kerber 4-6, 7-6 (5), 6-2 on Sunday.
Svitolina has never won a Grand Slam tournament. She had lost twice before to the 12th-seeded Halep in majors.
The 14th seed Indo-Croatian pair won 6-3 4-6 6-4 over their unseeded rivals in one hour and 56 minutes on Saturday night.
Rogers rallied from down 5-2 in the third set to upset Barty 6-2, 1-6, 7-5 (5) on Saturday night for the biggest win of the 28-year-old's career.
Her win streak may not yet rival the streaks set by Rafael Nadal, who won his first 31 matches in the French Open but they beat the alternative.
Djokovic moved into the fourth round at Flushing Meadows for the 14th consecutive appearance, coming back to beat Kei Nishikori 6-7 (4), 6-3, 6-3, 6-2.
The 11th-seeded Bencic eliminated No. 23 Jessica Pegula 6-2, 6-4 in a rematch from the Summer Games.
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