Bopanna and Dodig, seeded 13th, lost 7-6(4) 4-6 6-7(3) to fourth seeds Rajeev Ram and Joe Salisbury in the third round.
This was Andreescu’s first loss in the main draw at Flushing Meadows. She beat Serena Williams in the final to win the title in her debut two years ago and missed the hard-court Grand Slam tournament in 2020
Harris will face fourth seed Alexander Zverev in the last eight after the German moved past Italian Jannik Sinner 6-4, 6-4, 7-6(7).
Fernandez will be up against No. 5 seed Elina Svitolina while Alcaraz plays the final match of the day on Ashe against No. 12 seed Felix Auger-Aliassime
No. 1 Djokovic improved to 25-0 in majors this year by winning 1-6, 6-3, 6-2, 6-2 against 20-year-old Jenson Brooksby.
Following a tame defeat to Raducanu, Rogers said she kind of wished social media didn't exist, because hers was going to be filled with negativity.
The Olympic gold medalist from Switzerland beat Iga Swiatek 7-6 (12), 6-3 to make the last eight in Flushing Meadows for the third time.
Brooksby is a wild-card entry who began this season ranked outside the top 300 and is now a career-best 99th.
Muguruza reportedly told the reigning French Open champion that her behaviour was 'so unprofessional' after the match ended after 1 AM following Krejcikova's medical break.
A day before her 19th birthday, the unseeded left-hander from Canada grabbed the last five games to eliminate 2016 title winner Angelique Kerber 4-6, 7-6 (5), 6-2 on Sunday.
Svitolina has never won a Grand Slam tournament. She had lost twice before to the 12th-seeded Halep in majors.
The 14th seed Indo-Croatian pair won 6-3 4-6 6-4 over their unseeded rivals in one hour and 56 minutes on Saturday night.
Rogers rallied from down 5-2 in the third set to upset Barty 6-2, 1-6, 7-5 (5) on Saturday night for the biggest win of the 28-year-old's career.
Djokovic moved into the fourth round at Flushing Meadows for the 14th consecutive appearance, coming back to beat Kei Nishikori 6-7 (4), 6-3, 6-3, 6-2.
The 11th-seeded Bencic eliminated No. 23 Jessica Pegula 6-2, 6-4 in a rematch from the Summer Games.
The sixth-seeded Canadian had little trouble advancing with a 6-1, 6-2 victory over 104th-ranked Greet Minnen of Belgium
The unseeded Mirza and Ram lost 3-6 6-3 7-10 to their opponents in just 61 minutes on Friday night.
Osaka conceded a defeat against Canadian teenager Leylah Fernandez, who came up with an inspired performance on Friday evening to win 5-7, 7-6(2), 6-4.
Second seed Daniil Medvedev continued his perfect run in New York, cruising past Spaniard Pablo Andujar 6-0, 6-4, 6-3 to reach the fourth round for the third straight year.