Fidel Martinez and Paraguayan Pablo Aguilar scored in the first half for Tijuana, with the second goal allowed despite replays suggesting he was offside. Edgar Benitez scored for Toluca.
Tijuana is a newcomer to Mexico's first division and was promoted only last year, while Toluca is attempting to win its 11th title to equal Guadalajara Chivas as Mexico's most successful club.
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