Amla is still recovering from a finger injury while Duminy aggravated a right shoulder problem in South Africa's home series against Zimbabwe which will now need surgery.
Can a leopard change its spots? Or, put another way, can Australia soften their hard-nosed approach to cricket? And by doing so, can they still be successful?
Australia's defeat goes down as the heaviest by any team in terms of runs in Tests since 1934, and the fourth heaviest ever.
When bad light ended play early, Australia were reeling at 88/3 and 524 runs behind. Paceman Morkel trapped openers Matt Renshaw and Joe Burns.
South Africa ground their way toward a series win with an unbeaten 40-run partnership between Dean Elgar (39 not out) and skipper Faf du Plessis (34 not out).
The Aussie captain showed a great application in his 62-run knock while batting with a broken right thumb as Australia managed 221 in their first innings against South Africa on day 3 at the Wanderers.
Australia, with their morale in pieces following the cheating saga of the last week, were 110/6 and 378 runs behind at stumps on the second day of the series decider at the Wanderers.
Australia were feeling the pressure when Markram and de Villiers took South Africa to 247/2, setting the crowd off with the tampering taunts.
Kohli posted a special message for Markram on Twitter, hailing him for his noteworthy knock that was decorated with a six and 17 boundaries.
While Australia play to save the series and repair their reputation, South Africa are playing for a piece of history that has bugged them for years.
Smith admitted his guilt but the manner in which Cricket Australia's elaborate release on the charges levelled against him tried to portray him as the first among the equals of a rare breed of criminals.
The 31-year old batsman has outraged his devastated teammates by swilling champagne in the bar of the team hotel in Cape Town with non-cricket friends.
Ball-tampering row: Tough questions have also been asked by the Australian media over the involvement of coach Darren Lehmann, and if he knew about the plan.
The entire episode attracted worldwide attention and from fans to cricket pundits and former players, all launched a scathing attack on Steve Smith & Co.
MCC also called for a major shift in attitude and culture to preserve the game as the pre-meditated ball-tampering conspiracy, involving the under-fire Australian skipper has gained worldwide attention.
Cricket Australia's head of integrity Iain Roy and high-performance manager Pat Howard are in Cape Town and Roy "will immediately conduct his inquiries around the specifics of the ball-tampering incident" the Australian cricket body said.
As per the video surfaced on social media, Aussie batsman Cameron Bancroft was spotted appearing to pour sugar into his left pocket during the fifth Test in Sydney against England.
Australia captain Steve Smith was banned for one match by the ICC for his role in a ball-tampering plot in third Test against South Africa but Cameron Bancroft, the player who did the tampering, avoided a suspension.
Fast bowler Morne Morkel picked up 5/23 in Australia's second innings to give them their second-heaviest defeat to South Africa in terms of runs and its heaviest since 1970.
The Australia team, in a plot led by captain Steve Smith and senior players, confessed to ball tampering allegations against South Africa in the third Test at Cape Town on Saturday.
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