Stirling hit a strokeful 88-ball 70 laced with seven fours and two sixes, while Balbirnie anchored the Ireland innings to help the visitors win the series decider by 5 wickets.
Dananjaya was suspended from bowling after being reported during the first Test against England last year in November and subsequently underwent an independent assessment of his bowling action.
Experienced batsman Mohammad Hafeez, brought in for the ODIs, secured victory with 71 not out as his side finished on 267/5 to win with five balls to spare.
Coach Gray Stead said that the team's main priorities are on preparing a World Cup squad and a team capable of winning a series against India.
Sri Lanka made a solid start, helped by 71 from Danushka Gunathilaka. But a middle-order collapse left them facing a comprehensive defeat until Perera scared the hosts.
The Proteas were under pressure at 3/55 in the 16th over after being sent in to bat before du Plessis (125) led a comeback with Miller (139) to help the Proteas reach 320/5.
After Australia were bowled out for 231 after being sent in to bat, the home side restricted South Africa to 224 for nine, with Marcus Stoinis taking 3 for 35.
After undergoing a surgery on his injured finger, Imam returned to action on Friday in the semi-final of the Quaid-e-Azam Trophy One-Day tournament in Lahore.
A victory in the fifth and penultimate One-day International will ensure India maintain their unbeaten run since the reverse against South Africa in 2015.
Amla is still recovering from a finger injury while Duminy aggravated a right shoulder problem in South Africa's home series against Zimbabwe which will now need surgery.
As per the new BCCI constitution, 90 per cent tickets of the total capacity of the stadium must be put on public sale, which effectively leaves 10 per cent of complimentary tickets left with state units.
The Indian team is currently playing against England in the five-match Test series where they are lagging 1-3 after the fourth Test.
Follow the Live Score and Ball-by-Ball Commentary from Ireland vs Afghanistan, 3rd ODI at Belfast with IndiaTV Sports.
Angelo Mathews' unbeaten 97 helped Sri Lanka reach a challenging total of 299/8, however, Dananjaya's six-for proved too deadly for the visitors, bundling them out for 121.
Du Plessis was on Monday ruled out of the remainder of South Africa's tour of Sri Lanka, after injuring his shoulder while attempting a catch during the third one-dayer against the hosts.
Sri Lanka never looked in the hunt and were all out for 285 in 45.2 overs as the Proteas clinched the five-match series.
The game, which marked Nepal's entry into ODI cricket, saw the Paras Khadka-led side lose by 55 runs.
Kami achieved this feat in the third over of the match as he clean bowled Netherlands' opener Daniel ter Braak to claim his and Nepal's maiden ODI wicket.
In a lopsided series, Pakistan won two matches by nine wickets and two by more than 200 runs before wrapping up the series on Sunday.
Malik, who has been playing for nearly two decades, achieved this feat in his 266th ODI match against Zimbabwe.
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