Alzarri, who took a record 6 for 12 on his debut was hammered for 53 off three overs, primarily due to 28 runs conceded in the 13th over that changed the game.
Kishan batted at number four in place of Yuvraj who had managed to tally 98 runs in the first four games. He was run out for 17 against Sunrisers Hyderabad on Saturday.
Sent into bat, England Lions declared their innings at 145 for 6 in 60 overs.
The England Lions have had a tough tour thus far, losing four of the five limited-overs games and will expect to put up an improved show in the longer version.
Jharkhand's left-arm spinner Pappu Roy, rookie Mumbai fast bowler Tushar Deshpande, Andhra batsman Ricky Bhui have earned their places in the side.
Rahane dropped anchor to score an unbeaten 144 off 156 balls while the young Ishan Kishan smashed his way to an 87-ball 114 during their opening stand of 210 for India C.
In another match, Bengal trounced Team Rajasthan by six wickets. Gujarat was bundled out for 107 in 25 overs in a reduced game by Jharkhand, who overhauled the target in 21.4 overs.
In his third domestic match, Negi returned with extraordinary figures of 6-0-17-7 as Arunachal Pradesh batting caved in for 61 all-out.
Prithvi Shaw (70 off 61), Shreyas Iyer (54 off 45) and Ishan Kishan (50 off 46) helped India A amass 328/8 before the bowlers dismissed ECB XI for 203 in 36.5 overs.
Mumbai Indians reserve wicket-keeper Aditya Tare had words of praise for young Jharkhand stumper Ishan Kishan.
Kishan's day of reckoning finally came on Wednesday night with the 19-year-old smashing a brilliant 62 off just 21 balls to help Mumbai Indians' cause.
Mumbai Indians captain Rohit Sharma praised Ishan Kishan's fearless character and said he was the 'turning point' in his side's mammoth win over Kolkata Knight Riders.
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