Third seed Sindhu looked a pale shadow of herself as she lost 13-21, 16-21 in 40 minutes against seventh seed He Bingjiao of China.
Saina looked in good touch initially but couldn't match the pace of Tzu Ying, later on, to squander four-game points and lose the opening game.
Srikanth showed great determination to outwit Korea's world No 25 Lee Dong Keun 12-21, 21-16, 21-18 in a second-round clash that clocked an hour and 13 minutes.
World No. 10 Saina will face either 2017 world champion Nozomi Okuhara of Japan or Spain's Beatriz Corrales next. Fifth-seeded Srikanth will meet Korean Lee Dong Keun.
By virtue of this win, Sindhu has managed to break her hat-trick of losses against the American and equalled the head-to-head record at 3-3.
Hamilton trails Vettel by one point at the top of the standings heading into Sunday's race at the Paul Ricard Circuit.
After winning a record-extending 11th French Open title earlier this month, the Spaniard withdrew from the Queen's Club Championships, a key Wimbledon tune-up played in London from June 18 to June 24.
Halep has not played since beating Sloane Stephens for the Roland Garros title earlier this month.
After playing 27 matches on clay the past two months, the 32-year-old Spaniard feels he needs time to recover.
Federer or Nadal have won each of the past six major tournaments, equalling their second-longest stretch of dual dominance, their other six-slam streak came way back in 2008-09.
Prajnesh, who could have played at the French Open as 'lucky loser' but missed out since he had confirmed participation in an event in Italy, is satisfied at his progress.
Rafael Nadal and Simona Halep became the first pair of ATP and WTA No 1s to both win the title at Roland Garros since Jim Courier and Monica Seles in 1992.
Nadal led by two sets plus a break early in the third, when the middle finger on his racket-wielding left hand was cramping so badly he couldn't straighten it.
Nadal's form never wavered, though, and soon enough he was celebrating his 17th Grand Slam title overall, second among men only to Roger Federer's 20.
Simona Halep beat Sloane Stephens 3-6, 6-4, 6-1 for her first Grand Slam title.
The 32-year-old Spaniard is 10-0 in finals in Paris, winning the trophy every year from 2005-08, then again every year from 2010-14, then again in 2017.
Halep added Grand Slam trophy No. 1 to her No. 1 ranking, coming back from a set and a break down to beat Sloane Stephens 3-6, 6-4, 6-1.
Sloane Stephens enters Saturday's French Open final against No. 1 Simona Halep with a 6-0 record in tournament title matches.
The No. 1-ranked Nadal compiled a 35-20 edge in winners while making only 19 unforced errors on Friday.
Del Potro is playing in the French Open semi-finals for the first time in nine years.
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