The sudden changes coincide with the induction of former Test captain Ramiz Raja as the new PCB chairman on September 13.
The limited-overs series gets underway with the first ODI in Cardiff on July 8. Pakistan will play three ODIs and as many T20Is against the host
Shadab was diagnosed with "high grade full thickness tear to the Rectus Femoris muscle", an injury he had sustained during his side's four wickets victory over New Zealand in the Napier T20I earlier this week.
As Shadab is not available for, at least, the Boxing Day Test, the team management has included left-arm spinner Zafar Gohar as a reinforcement.
Vaughan's comment came after Shadab was replaced by Fawad Alam for the second Test against England at the Ageas Bowl in Southampton.
Pakistan's tour of England begins on July 30 with a three-match Test series. This will be followed by a three-match T20I series from August 29 to September 2.
The results have hence put their participation in the impending England tour in doubt.
Several counties such as Yorkshire, Kent, Lancashire, Gloucestershire and Hampshire were forced to cancel contracts of their overseas players, including Indian cricketers Cheteshwar Pujara and R Ashwin.
Chris Gayle was at his destructive best in the GT20 League, as he smacked 32 runs off a single over of Shadab Khan.
Yuvraj Singh shined with the bat in his second game in GT20, scoring 35 off 21 deliveries in a 2-wicket win for Toronto Nationals.
Shadab was named in Pakistan's 15-member World Cup squad but couldn't fly with the team to England after tests revealed traces of hepatitis C in his blood stream.
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