Madrid, Nov 21: Real Madrid can clinch top spot in Group D of the Champions League with a victory against Dinamo Zagreb, while Lyon knows a loss against Ajax will see it miss out on the knockout stages for the first time since the 2002-03 season.
Madrid has won all four of its group matches without conceding a goal, while its Croatian opponent is winless and still looking for its first goal of the tournament.
Madrid's 3-2 win over Valencia on Saturday was its 11th straight in all competitions to stay top of the Spanish league ahead of Barcelona.
Ajax can secure its place in the last 16 with a win in France. The Dutch club is three points ahead of Lyon with only one game to play after this week's round.