Alcaraz won 6-3, 4-6, 7-6 (2), 0-6, 7-6 (5) in just over four hours to become the youngest man in the fourth round at Flushing Meadows since Pete Sampras and Michael Chang in 1989.
The third-seeded Tsitsipas hit 27 aces and beat Mannarino 6-3, 6-4, 6-7 (4), 6-0 at Arthur Ashe Stadium.
Murray did not appreciate that Tsitsipas took a medical timeout after the third set and made a lengthy visit to the locker room after the fourth.
Murray goes down in fight set to a much younger Tsitsipas in a hard fought battle 6-2, 6-7 (7), 6-3, 3-6, 4-6.
The last time Tsitsipas squared off against a Grand Slam champion at a major, he came up agonisingly short, having led Serbia's Novak Djokovic
The other men's tennis stars to be seen in Tokyo include two-time Olympic gold medallist Andy Murray of Great Britain, Germany's Alexander Zverev and Argentina's Diego Schwartzman.
The 57th-ranked Tiafoe applied pressure by charging the net often and won 6-4, 6-4, 6-3. He had been 0-11 previously against players ranked in the top five.
Tsitsipas posted on social media that his “very beloved grandmother lost her battle with life” five minutes before he entered the court Sunday for his first Grand Slam title match.
Novak Djokovic fought back from two sets down to beat the Greek fifth seed Stefanos Tsitsipas 6-7(6) 2-6 6-3 6-2 6-4 to win the French Open title for the second time on Sunday.
Novak Djokovic defeated Stefanos Tsitsipas in five sets to win the 2021 French Open.
However, history says that Nadal slayers at the Roland Garros have never won the French Open title.
Djokovic will be trying to win 19th Grand Slam title in his 29th appearance in a major final. The 22-year-old Tsitsipas will be appearing in his first Grand Slam final.
Djokovic has won five of their previous seven encounters, although Tsitsipas did push him to five sets before losing in the semifinals of the 2020 French Open.
The 22-year-old needed five match points to complete a 6-3, 6-3, 4-6, 4-6, 6-3 win over world No.6 Zverev in three hours and 37 minutes.
It will be the youngest matchup in the men's semifinals at Roland Garros since a couple of guys named Rafael Nadal and Novak Djokovic met in 2008.
Daniil Medvedev arrived in Paris with a lifetime record of 0-4 at the French Open, but he’s 4-0 this year and has advanced to a quarterfinal showdown Tuesday night against Stefanos Tsitsipas.
The inevitable question remains - can Nadal beat the odds, once again, to lift an unprecedented 14th on la terre battue?
Nadal roared out to a 5-1 lead before Carreno pulled back a break. Carreno then had three break chances on Nadal’s next service game, but the latter saved them all and closed out the set.
Fourth-seeded Tsitsipas was in dominant form as he edged 4-3 ahead of the sixth-seeded Russian in their career meetings, having also beaten him on clay last year in the French Open quarterfinals.
The big-serving Greek's opponent will be sixth-seeded Russian Andrey Rublev, who beat unseeded Norwegian Casper Ruud 6-3 7-5. He aims for his second title of the year and ninth overall.
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