De Bruyne, who has only just returned from two months out with ligament damage in his right knee, now has the same problem in his left knee.
The injury means he will miss at least four of the six games in the group stage of the Champions League and the next 11 games in the 38-match Premier League season.
City said they were unclear how long the Belgian will be sidelined because "the extent of the problem is not yet known" and that more tests on the knee are needed.
Belgium overcame five-time world champions Brazil 2-1 on Friday to book their place in the semi-finals of the FIFA World Cup only for the second time after a gap of 32 years.
Liverpool star Mohamed Salah is likely to stay at the club despite interest from Spanish giants Real Madrid after a record breaking goalscoring season.
The former Chelsea player has scored 41 goals in 46 appearances in all competitions for Liverpool — enabling him to beat Manchester City midfielder Kevin De Bruyne in second place to the PFA award.
Berlin: Kevin de Bruyne created both goals for Wolfsburg to beat Hamburger SV 2-0 and consolidate second place in the Bundesliga on Sunday.Ivica Olic opened the scoring in the 26th minute, deflecting de Bruyne's wayward
SALVADOR, Brazil : Romelu Lukaku had a point to prove at the World Cup. After Belgium missed countless chances during the 90 minutes of regulation time in the second-round match against the United States on
SALVADOR, Brazil : They captured the eyes and hearts of a suddenly awakened soccer nation, who gathered in unprecedented numbers to watch the world's game.But the end of the ride came at the exact same
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