They follow another senior player, Gerard Pique, in taking a salary reduction to enable their financially troubled club to register new players and fit into the league’s strict financial fair play regulations.
Barcelona said medical tests showed that Aguero has a tendon injury in his right calf and will be sidelined for about 10 weeks.
Defender Juan Foyth and striker Lucas Ocampos are the most notable absentees from the 28-player squad, despite featuring regularly since Lionel Scaloni became head coach in 2018.
Barcelona said Agüero will be with the club beginning on July 1, after his contract with Manchester City expires.
The 32-year-old Argentinian will bring an end to a record-breaking decade at the club after Saturday's Champions League final against Chelsea in Porto.
City’s record scorer, who is leaving the club following next week’s Champions League final after 10 years at the Etihad Stadium, hit a quickfire double after coming off the bench with 25 minutes remaining.
A major subplot in Tuesday’s Champions League quarterfinal between City and Borussia Dortmund — particularly in light of the announcement about Aguero’s departure — centers around Erling Haaland
The 32-year-old Argentina striker has 257 goals for City, the most famous being his stoppage-time winner against Queens Parks Rangers on the final day of the 2011-12 season that clinched the team its first league title in 44 years.
Aguero missed the end of last season and the start of the current campaign after undergoing knee surgery in June.
Sergio Aguero picked up an injury during Manchester City's 5-0 win over Burney in the Premier League on Monday.
Phil Foden and Riyad Mahrez both scored twice, with David Silva adding the other goal.
Aguero called up Messi and chatted with him for a few minutes while streaming the entire episode live for his fans.
Footballers Sergio Aguero, Thibaut Courtois and Arthur will make their Formula One Esports debut in the Spanish Grand Prix.
The Premier League is hoping to return to action by June 8 in a bid to complete the season.
Aguero has scored 254 times in 368 matches for City, including the stoppage-time goal against Queens Park Rangers in 2012 that clinched their first top-flight title in 44 years.
Manchester City striker Sergio Aguero is using his time to teach the British kids to speak Spanish.
Sergio Aguero saw his spot kick saved but was spared by Gabriel Jesus, who came on as a substitute for his fellow striker and scored an 80th-minute winner.
The Argentina striker tapped in at the far post in the 73rd minute following another perfectly weighted cross from Kevin De Bruyne, giving the Belgian his 15th assist of the campaign.
Beyond the records for Aguero - now the league's all-time top-scoring foreign player on 177 goals and scorer of most hat tricks by any player with 12 — the whole City team shone in yet another big win.
Aguero scored his 175th and 176th career EPL goals on Sunday for Man City at Aston Villa in his 255th league appearance.
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