On a day when rest of the Indian shuttlers found the going tough, World No. 3 Sindhu continued her impressive run with a 21-16, 21-14 win over Hong Kong's Yip Pui Yin.
Nehwal slumped to an 18-21, 15-21 straight set defeat to her Chinese opponent Chen Yufei in the second round of the Indonesia Open.
Olympic and world championship silver medallist Sindhu brushed aside the challenge of Malaysia's Ying Ying Lee 21-8, 21-14 to set up a clash Carolina Marin.
The Indian has been drawn in a tough group and is meeting second seed Akane Yamaguchi of Japan in the second round.
The Gold Coast loss was Sindhu's third successive against the Saina, following defeats at the 2017 National championship final and 2018 Indonesia Open quarterfinal.
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After going down 1-4 to Canada in the opening match, Saina and Co. seemed to get their act together as they won all the matches, except the first women's doubles.
The tournament which is in its 27th year of existence will see the Asian championship bronze medallist Prannoy along with B Sai Praneeth in the men's singles.
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While Saina is an Olympic bronze medallist, Sindhu did one better by winning a silver at the Rio Olympics in 2016.
London Olympics bronze medallist Saina has a 3-1 head-to-head record in the international matches against Rio Games silver medallist Sindhu.
Her frequent losses in the finals and the accompanying criticism does not affect ace shuttler PV Sindhu, who said playing in the summit showdown of a tournament itself is "a big achievement". Asked about her rivalry with Saina, she said, "The rivalry
Former world No 1 Saina showed her class as she dumped unseeded Korean Lee Jang Mi 21-15 21-13 in a 43-minute clash.
Third seed Sindhu, who won a silver at the Commonwealth Games, notched up a commanding 21-12 21-15 win over another Chinese Chen Xiaoxin in another pre-quarterfinal match.
Saina, who had clinched a gold medal at Gold Coast, continued her good run as she brushed aside Singapore's Yeo Jia Min 21-12 21-9.
Saina, who won the women's singles gold, said winning the team championship was more satisfactory for her.
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The Delhi girl set the real and the virtual world on fire following her jaw-dropping feat with none other than Prime Minister Narendra Modi leading the chorus of congratulatory messages.
Sindhu, who led the Indian contingent at the glittering opening ceremony which launched the CWG in Gold Coast, was defeated by her compatriot Saina Nehwal in the much-anticipated women's singles summit clash.