In this franchise, Gargamel the wizard is flourishing in Paris. But he is running out of his magical powers. So he creates a group of mischievous Smurf-replicas called the Naughties; Smurfette (voiceover by Katy Perry), Vexy (voiceover by Christina Ricci) and Hackus (voiceover by J.B. Smoove) to obtain the all-powerful, magical Smurf-essence. Apparently, this concoction would help Gargamel to rule the world.
Unfortunately for him, things don't work according to his plans. Smurfette, the cute blonde naughty, who he had sent to snoop and rob the Smurfs of their "Smurf-essence", is a changed individual as she "chooses to be a Smurf".
So, he with the help of Vexy and Hackus kidnaps Smurfette from Smurf-land and imprisons her in Paris.
Laced with familial bonding, an adventurous flight around Paris and emotional blackmail what follows is the Smurfette-rescue operation. Papa Smurf (voiceover by Jonathan Winters) along with Smurfanity, Grouchy and Narcissi-murf (voiceover by George Lopez, Anton Yelchin and John Oliver respectively) traverse to Paris and in collaboration with their human friends - Patrick (Harris), Grace (Mays) Winslow and Victor (Brendon Gleeson), they rescue Smurfette.
The plot is layered with lessons like dealing with different types of parents - real parents, adoptive parents to stand-in parents. It is strongly underlined with the moral, "It does not matter from where you come, what matters is what you choose to be."
