The unseeded Wawrinka beat top-seeded Kei Nishikori 6-2, 4-6, 6-4 in the ABN AMRO World Tournament semifinals to face Gael Monfils for the title on Sunday.
Novak Djokovic, Alexander Zverev, Stan Wawrinka, Milos Raonic and Kei Nishikori were all off to winning starts in the first round of Australian Open.
Murray hadn't played in a Grand Slam tournament since Wimbledon last year, before needing hip surgery that has limited him to just eight matches this year.
Returning to the place where he claimed the second of his three Grand Slam titles did not help Wawrinka shake off his poor form.
Wawrinka was swept aside by Marton Fucsovics of Hungary 6-4, 6-0 in the quarterfinals for his first defeat in front of home fans at Geneva since 2015.
It was the first win in an ATP tournament for the 21-year-old Dutchman, who dominated the second and third sets against a lacklustre Wawrinka.
Federer will next face Frenchman Richard Gasquet in the round of 32 on Saturday.
Stan Wawrinka never looked capable of winning his third-round match, losing 6-2, 6-1, 6-4 to American Tennys Sandgren.
Wawrinka is also looking for a new coach to work alongside Yannick Fattebert after Magnus Norman decided to retire in October.
Earlier, Djokovic was expected to make a return in 2018, but the former world number one has decided to start his season early at the Mubadala World Tennis Championship, beginning in Abu Dhabi on December 28.
The Chennai Open will now be held in Pune next year and would be henceforth called "Maharashtra Open".
Stan Wawrinka - No.3 ranked iced his knee during changeovers and never was able to summon his best tennis at the Centre Court of All England Club.
A brief look at some of the players who are capable of breaking their dominance of Big 4 in Tennis at the All England Club.
Rafael Nadal won his record 10th French Open title, beating No.3 Stan Wawrinka in straight sets.
'Stan the Man' defeated world number one Andy Murray in a grueling five-setter to set a date against 'King of Clay' Rafael Nadal in the final of men's singles at French Open 2017.
third seed Stan Wawrinka beat the defending champion Novak Djokovic 6-7(1), 6-4, 7-5, 6-3 to clinch his maiden US Open title, his third Grand Slam trophy.
Shanghai: Rafael Nadal beat a top-five player for the first time in more than a year by defeating Stan Wawrinka 6-2, 6-1 Friday to reach the semifinals of the Shanghai Masters.The fourth-seeded Wawrinka missed wildly
Paris: Stan Wawrinka won the French Open by beating No. 1-seeded Novak Djokovic 4-6, 6-4, 6-3, 6-4 in the final Sunday, thwarting Djokovic's bid to complete a career Grand Slam.The eighth-seeded Wawrinka, so long in
Paris: One year after his first-round loss in Paris, Stan Wawrinka will be playing in the final of the French Open. The eighth-seeded Swiss player advanced to his first final at Roland Garros with a
Paris (AP): Stumbling on his way to the net, Roger Federer dropped his racket and fell to his knees on the red clay. Hardly the sort of grace and precision the world has come
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