The double Olympic medallist bowed out of the Denmark Open after losing in straight games to world no 8 Korean An Seyoung in the women's singles quarterfinals.
Srikanth, who had claimed the title in 2017, outsmarted compatriot B Sai Praneeth 21-14 21-11 in 30 minutes.
Sindhu, a bronze medallist at the Tokyo Olympics, had taken a break due to the hectic schedule but she would be itching to make a winning return at the Denmark Open.
The fifth seed Indian took 33 minutes to get the better of his Canadian opponent 21-15 21-14 in the men's singles second round match of the Super 750 tournament, the only event happening this year in Badminton World Federation's calendar.
Kidambi opens against world no 52 Toby Penty of England in the second half of the draw while Shubhankar Dey and Ajay Jayaram will look to go deep into the tournament.
Rest of the Indian squad, including Lakshya Sen, Kidambi Srikanth and Shubhankar Dey, flew with Air France from Delhi on Thursday night.
The BWF World Tour was shut down following the completion of the All England Championships in March due to the COVID-19 pandemic.
The 19-year-old claimed five titles in the senior circuit last year, including two BWF World Tour Super 100 top honours — SaarLorLux Open and Dutch Open.
Srikanth will open against England's Toby Penty and may face fellow Indian Subhankar Dey in the second round. For Saina, France's Yaelle Hoyaux awaits her in the women's singles opener.
SAI will also bear the cost for Srikanth's COVID-19 testing that is required to be done before he takes part in the competition.
The Thomas and Uber Cup Finals, scheduled to be held from October 3 to 11 in Aarhus, Denmark is the first tournament in the revised calender, which was launched by the sport's governing body BWF last week.