Venus Williams' 22nd appearance at the French Open did not last long.
The 2002 runner-up lost her opening match at Roland Garros for the second year in a row, beaten 6-3, 6-3 by ninth-seeded Elina Svitolina in 1 hour, 13 minutes.
The 38-year-old Williams lost in the first round for the fourth time in the last seven years at the clay-court Grand Slam tournament.
Wiliams was broken in seven of her nine service games.
While playing his first match at Roland Garros since 2015, Roger Federer had no problem reaching the second round of the French Open.
Back on the refurbished Court Philippe Chatrier on the opening day of the clay-court event, the 20-time Grand Slam champion defeated French Open debutant Lorenzo Sonego 6-2, 6-4, 6-4.
Federer missed the French Open in 2016 because of a back injury and then skipped the event to focus on Wimbledon. He won the title in Paris 10 years ago to complete a career Grand Slam.
"I missed you, thanks very much for the welcome," Federer said to the crowd after concluding his match. "I was quite tense at the start."