The drug had been used successfully for treating psoriasis in humans. It had also reversed alopecia areata, a less extreme form of alopecia, in mice.
"There are no good options for long-term treatment of alopecia universalis. The best available science suggested this might work, and it has," said King.
After two months on tofacitinib at 10 mg daily, the patient's psoriasis showed some improvement, and the man had grown scalp and facial hair the first hair he'd grown there in seven years.
After three more months of therapy at 15 mg daily, the patient had completely regrown scalp hair and also had clearly visible eyebrows, eyelashes, and facial hair, as well as armpit and other hair, the doctors said.
"By eight months there was full regrowth of hair. The patient has reported feeling no side effects, and we've seen no lab test abnormalities, either," said co-author Brittany G Craiglow.
To facitinib appears to spur hair regrowth in a patient with alopecia universalis by turning off the immune system attack on hair follicles that is prompted by the disease, King said.
The research was published in the Journal of Investigative Dermatology.
