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Scientists identify new gene as type 2 diabetes culprit

Scientists have identified a new gene which they believed is a culprit behind Type-2 diabetes. Using the gene editing technology called CRISPR and other sophisticated scientific tools, researchers have identified this gene, ACSL5. As per

India TV Lifestyle Desk, New York [ Published on: September 01, 2016 17:10 IST ]
Researchers identifies new culprit Type-2 diabetes gene
Researchers identifies new culprit Type-2 diabetes gene

Scientists have identified a new gene which they believed is a culprit behind Type-2 diabetes.

Using the gene editing technology called CRISPR and other sophisticated scientific tools, researchers have identified this gene, ACSL5.

As per scientists, this new gene ACSL5 (codes for a protein that regulates how the body recognises insulin) may represent an important target for future treatments for the disease.

"Type-2 diabetes is increasingly common, with an impact on millions of people," said study leader Struan Grant from The Children's Hospital of Philadelphia (CHOP) in the US.

"But it has complex causes, involving multiple genes and environmental influences, and we are still learning the details of its complicated biology. Our goal in investigating these biological functions is to develop more effective therapies," Grant said.

Because the gene codes for the enzyme, acyl CoA synthesase 5, that plays a role in lipid metabolism, developing drugs to act on this enzyme might help patients with Type-2 diabetes by increasing their sensitivity to insulin - an underlying issue in the disease,said the study.

However, much remains to be learned about the action of the newly identified culprit gene, the authors cautioned.

The study has been published in the journal Diabetologia.

(With agency input)

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