New Delhi: Ear infection is the one of the commonly diagnosed childhood illness. The most common symptoms of this infection are severe ear pain, trouble sleeping and fever.
Now ear infections could soon be easier to treat. Researchers including one of Indian-origin have found that a single dose of a new bioengineered gel may deliver a full course of antibiotic therapy for middle ear infections, making treatment for this common childhood illness much easier and potentially safer.
Middle-ear infection, or otitis media, is the number one reason for pediatric antibiotic prescriptions, but getting oral antibiotics into young children several times a day for seven to 10 days is a daunting task, said researchers led by Boston Children's Hospital in the US. Incomplete treatment and frequent recurrence of otitis media (40 per cent of children have four or more episodes) encourage the development of drug-resistant infections.
Since high doses are needed to get enough antibiotic to the ear, side effects like diarrhoea, rashes and oral thrush are common. Previously, the eardrum (also called the tympanic membrane) was an impenetrable barrier, said researchers, including Vishakha Sabharwal of Boston Medical Centre.
The bioengineered gel gets drugs past it with the help of chemical permeation enhancers (CPEs). The CPEs insert themselves into the membrane, opening up molecular pores that allow the antibiotics to seep through.
When tested in chinchillas (rodents with a hearing range and ear structure similar to those of humans), the gel dispensed high concentrations of the antibiotic ciprofloxin in the middle ear and completely cured ear infections due to Haemophilus influenza in all the 10 animals.
Ordinary ciprofloxacin ear drops cleared the infection in only 5 of 8 animals by day 7.
There was no observable toxicity, and no antibiotic was detected in the animals' blood. Yang and Kohane observed a slight hearing loss, similar to that caused by earwax.
Giving less of the gel alleviated the problem. The findings were published in the journal Science Translational Medicine.
(With agency input)