The evaluation made by these researchers specifically conclude the role of Plasminogen activator inhibitor-1 (PAI-1), which inhibits the breakdown of blood clots and is thus a risk factor for blood clotting, one of the major contributors to heart attack and ischemic stroke.
They have also found out that a robust circadian rhythm in circulating PAI-1 with a peak is corresponding to approx around 6:30 a.m. in a regular sleep/wake cycle.
