It will be France's searing speed led by Kylian Mbappe and Antoine Griezmann against Uruguay's defense anchored by Diego Godin on Friday in Nizhny Novgorod in the first World Cup quarterfinal.
Meanwhile, in the second quarterfinal of the day, Brazil will face a tough challenge in form of Belgium. Belgium is the competition's top scorer with 12 in its four games, with the goals spread around the team. Lukaku has four but seven of his teammates have scored, too.
Though Brazil has yet to hit the heights on the attacking front, it has one of the meanest defenses in the competition, conceding just one goal apiece in four matches.
Here's what to watch for in Friday's matchups at the World Cup quarterfinals:
TEAMMATES VS. TEAMMATES
The first match features a number of teammates on their professional clubs facing off against each other when France takes on Uruguay in Nizhny Novgorod. France forward Antoine Griezmann plays at Atletico Madrid alongside Uruguayan defenders Diego Godin and Jose Maria Gimenez; Godin is godfather to Griezmann's daughter. Those ties are so thick that Uruguay striker Luis Suarez needled Griezmann this week for trying to be Uruguayan . Suarez himself will find a Barcelona teammate on the other side of the pitch in French defender Samuel Umtiti.
With so much talent on both sides, the late game in Kazan features even more intrasquad intrigue: Manchester City's Gabriel Jesus, Fernandinho and Danilo against teammates Vincent Kompany and Kevin De Bruyne of Belgium; Brazil's Willian against Chelsea teammates Eden Hazard, Michy Batshuayi and Thibaut Courtois, all Belgian; and Belgium's Thomas Meunier against his Brazilian teammates at Paris Saint-Germain — Marquinhos, Thiago Silva and Neymar.
SPEED AND SKILL VS. SOLID D
Belgium is scoring almost a goal a game more than any other team in the tournament, with 12 in four matches. Brazil, to the surprise of some, has allowed just one goal in its four games. Only one other team has been that stingy: Uruguay, which will face a France attack loaded with speed and scorers. In both cases, something will have to give.
NEYMAR BEING NEYMAR
The most expensive player in the world has had a strong tournament so far and is the biggest star whose team is still alive. Some think Neymar could even win his first FIFA player of the year award if Brazil wins it all. But he's increasingly catching grief about his flopping , diving and writhing around after minor contact. Will that prompt the referee to give the Belgian defenders more leeway, or will Neymar keep getting the calls?
(With AP Inputs)