The ODI series triumph was offset slightly by a loss in the closing match but that would hardly dent the Indian women's cricket team's confidence as it heads into a five-game Twenty20 rubber against South Africa, starting in Potchefstroom on Tuesday.
After commanding victories in the first two ODIs, Indian women lost by seven wickets in the third ODI last Friday. The loss, however, hardly made any difference as the Indians had pocketed the three-ODI series by then.
The defeat definitely came as a jolt but Indian women would look to shrug off the disappointment and make a winning start to their T20 campaign.
The visitors were at their dominating best in the first two ODIs, recording huge 88 and 178-run wins before slumping to the loss.
Harmanpreet will be assisted by in-form batswoman Smriti Mandhana.
India would also be bolstered by the inclusion of T20 specialist Anuja Patil and debutant all-rounder Radha Yadav and wicketkeeper Nuzhat Parveen in the squad.
The T20 squad also features 17-year-old Mumbai player Jemimah Rodrigues, who had grabbed headlines after scoring 202 in 163 balls in an Under-19 game.
After a rare failure in last ODI, the Indians would be relying heavily on Mandhana to provide a solid start to the innings.
India's success also relies heavily on skipper Harmanpreet and Mithali Raj's contributions.
On the bowling front, veteran Jhulan Goswami is expected to return to the playing eleven after being rested for the third ODI.
In Jhulan's absence, the Indian bowling attack lacked sting in the last match as Mignon du Preez scored a valiant 90 to pull off a consolation win for South Africa.
Du Preez was ably assisted by opener Laura Wolvaardt (59) as the duo laid the foundation for a successful run chase.
Among the South African bowlers, left-arm pacer Shabnim Ismail would look to carry on her impressive form.
She did the maximum damage to India in the last ODI picking up four wickets while conceding just 30 runs from her nine overs.
India: Harmanpreet Kaur (captain), Smriti Mandhana (vice-captain), Mithali Raj, Veda Krishnamurthy, Jemimah Rodrigues, Deepti Sharma, Anuja Patil, Taniya Bhatia, Nuzhat Parveen Poonam Yadav, Rajeshwari Gayakwad, Jhulan Goswami, Shikha Pandey, Pooja Vastrakar, Radha Yadav.
South Africa: Dane van Niekerk (captain), Marizanne Kapp, Trisha Chetty, Shabnim Ismail, Ayabonga Khaka, Masabata Klaas, Sune Luus, Odine Kirsten, Mignon du Preez, Lizelle Lee, Chloe Tryon, Nadine de Klerk, Raisibe Ntozakhe, Moseline Daniels.
Match starts: 4:30 PM (IST).