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In Agneepath, the late actor Vikram Gokhale played the role of police commissioner M. S. Gaitonde. The movie starred Amitabh Bachchan in the leading role. In its remake with Hrithik Roshan, Om Puri played the character essayed by Gokhale.
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Vikram Gokhale played Acharya Yagyaprakash Bharti in Priyadarshan-directed horror-comedy Bhool Bhulaiyaa, starring Akshay Kumar, Vidya Balan, Shiney Ahuja, Ameesha Patel, and Paresh Rawal among others, in 2007.
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Hum Dil De Chuke Sanam was released in 1999 in which the late actor played Pundit Darbar, who doesn't allow his daughter Nandini (Aishwarya Rai) to tie the knot with Sameer (Salman Khan) and instead fixes her marriage with Vanraj (Ajay Devgn).
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Based on India's successful Mangalyaan mission, the veteran actor played Shrikant Bhosle, the director of Indian Space Research Organisation (ISRO) in the 2019 film led by Akshay Kumar and several female actors.
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In Anubhav Sinha's musical romantic drama 'Tum Bin' released in 2001, Gokhale played Girdhari Shah, the father of Raqesh Bapat's character Amar Shah whose accidental death forms the basis of the rest of the plot.